• 提示：詳情請(qǐng)下載說(shuō)明書(shū)。

• 產(chǎn)品描述： YK-4-279 blocks RNA Helicase A (RHA) binding with EWS-FLI1 (oncogenic protein). YK-4-279 induces apoptosis and shows anti-proliferation activities towards various cancer cells. YK-4-279 has a chiral center and it can be separated into two enantiomers. YK-4-279 can be used for the research of cancer

• 靶點(diǎn)： IC50: 0.94 μM (TC32), 1.83 μM (TC71), 1.03 μM (RDES), 0.33 μM (SKES), 0.94 μM (MMH-ES-1), 0.60 μM (STA-ET 7.2), 1.46 μM (A4573), 4.95 μM (PC3), 22.82 μM ( MCF7), 0.82 μM (MDA-MB-231), 1.514 μM (PANC1), 14.28 μM (ASPC1);Apoptosis;DNA/RNASynthesis

• 體內(nèi)研究：
  YK-4-279 (1.5 mg; i.p. once) inhibited ESFT tumor growth

• 參考文獻(xiàn)：
  1. Erkizan HV, et al. A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing's sarcoma. Nat Med. 2009 Jul;15(7):750-6. 2. Barber-Rotenberg JS, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 2012 Feb;3(2):172-82.

• 溶解性： DMSO  :  25  mg/mL  (68.27  mM;  Need  ultrasonic)

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.731 ml	13.654 ml	27.307 ml
  5 mM	0.546 ml	2.731 ml	5.461 ml
  10 mM	0.273 ml	1.365 ml	2.731 ml
  50 mM	0.055 ml	0.273 ml	0.546 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶(hù)參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *