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• 產(chǎn)品描述： Difluprednate(Durezol) is a corticosteroid, approved for the treatment of post-operative ocular inflammation and pain.

• 體內(nèi)研究：
  Difluprednate emulsion is rapidly deacetylated in the aqueous humor to difluoroprednisolone butyrate (DFB) in rats and rabbits, the drug's active metabolite, which has a similar corticosteroid activity profile. Radio-labeled difluprednate is instilled in the right eyes of pigmented rabbits in a separate study examining DFBA excretion. Difluprednate (0.05% emulsion) results in higher aqueous humor concentrations than the suspension form in the eyes of rabbits. Difluprednate concentrations ≥0.01% shows a statistically significant inhibition of inflammation compared to saline in a rabbit model, with the anti-inflammatory response proceeding in a dose-dependent manner. Difluprednate suppresses uveitis in all three concentration (0.002%, 0.01%, and 0.05%) in a dose-dependent manner in rats, and difluprednate 0.05% shows statistically superior anti-inflammatory activity compared to Betamethasone (0.1%).

• 參考文獻(xiàn)：
  1. Donnenfeld ED, et al. Clin Ophthalmol, 2011, 5, 811-816. 2.Jamal KN, et al. Clin Ophthalmol, 2009, 3, 381-390.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存條件： 2-8℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	1.966 ml	9.832 ml	19.664 ml
  5 mM	0.393 ml	1.966 ml	3.933 ml
  10 mM	0.197 ml	0.983 ml	1.966 ml
  50 mM	0.039 ml	0.197 ml	0.393 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *