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• 產(chǎn)品描述： CH-223191 is a potent and specific antagonist of aryl hydrocarbon receptor (AhR). CH-223191 inhibits TCDD-mediated nuclear translocation and DNA binding of AhR, and inhibits TCDD-induced luciferase activity with an IC50 of 0.03 μM

• 靶點： Aryl Hydrocarbon Receptor;AhR;ArylHydrocarbonReceptor

• 體內(nèi)研究：
  CH-223191 (10 mg/kg; once a day; 25 days) suppresses cytochrome P450 1A1 expression and the intrahepatocyte fat content in liver, reduces activity of AST and ALT in TCDD-treated mice

• 參考文獻：
  1. Kim SH, et al. Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor. Mol Pharmacol. 2006 Jun;69(6):1871-8. Epub 2006 Mar

• 溶解性： DMSO  :  62.5  mg/mL  (187.47  mM;  ultrasonic  and  warming  and  heat  to  60°C)

• 保存條件： 2-8℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.999 ml	14.997 ml	29.995 ml
  5 mM	0.6 ml	2.999 ml	5.999 ml
  10 mM	0.3 ml	1.5 ml	2.999 ml
  50 mM	0.06 ml	0.3 ml	0.6 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

• 2. [IF=7.3] Yi Ying et al."Astragalus Polysaccharide Protects Experimental Colitis Through An AhR-Dependent Autophagy Mechanism."BRITISH JOURNAL OF PHARMACOLOGY.2023 Aug;:

• 1. [IF=18.9] Zheng-Meng Jiang et al."Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation."Science Bulletin.2023 Jun;:

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *