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• 產品描述： AZD1208 is a novel, orally bioavailable, highly selective PIM kinase inhibitor with single nanomolar potency against all three PIM kinases.

• 靶點： Apoptosis;Autophagy;Pim;Apoptosis;?Pim;?Autophagy

• 體內研究：
  AZD1208在培養(yǎng)的MOLM-16細胞中引起細胞周期停滯和細胞凋亡。 這伴隨著BAD,4EBP1和p70S6K磷酸化的劑量依賴性降低。 另外,AZD1208導致有效抑制來自骨髓抽吸物的原代AML細胞的集落生長并下調Pim靶標的磷酸化

• 細胞實驗： AZD1208 is dissolved in DMSO. MOLM-16 cells, purchased from DSMZ and cultured in RPMI containing 10% fetal bovine serum (FBS) and 1% L-glutamine, are plated at 20,000 cells per well in 96 well plates overnight. Cells are treated for 72 hours with compound or control vehicle (dimethyl sulfoxide) and cell viability is measured after the addition of Cell Titer-Blue for 4 hours at 37?C and reading of fluorescence on a Tecan Infinite? 200. The GI50 is determined by calculating growth at each dose relative to vehicle treated cells and cell viability at the time of treatment.

• 參考文獻：
  1.Erika Keeton, et al. 53rd ASH Annual Meeting (2011) Abstract nr 1540

• 溶解性： DMSO:7.6  mg/mL  (20  mM)),with  gentle  warming

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.635 ml	13.176 ml	26.352 ml
  5 mM	0.527 ml	2.635 ml	5.27 ml
  10 mM	0.264 ml	1.318 ml	2.635 ml
  50 mM	0.053 ml	0.264 ml	0.527 ml

• 注意：部分產品我司僅能提供部分信息，我司不保證所提供信息的權威性，僅供客戶參考交流研究之用。

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本計算器可幫助您計算出特定溶液中溶質的質量、溶液濃度和體積之間的關系，公式為：

質量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *