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• 產(chǎn)品描述： BRD73954 is a potent HDAC inhibitor and selectively inhibiting both HDAC6 and HDAC8 with IC50 values of 0.0036, 0.12, 9, 12, 23 μM for HDAC6, HDAC8, HDAC2, HDAC1 and HDAC3, respectively. BRD73954 decreases the levels of HDAC6, associated with upregulation of Ac-Tubulin

• 靶點： HDAC6:0.036 μM (IC50);HDAC8:0.12 μM (IC50);HDAC2:9 μM (IC50);HDAC

• 體外研究：
  BRD73954 (10 μM; 48 h; HeLa cells) inhibits HDAC6 activity via upregulation of Ac-Tubulin. Western Blot Analysis Cell Line: HeLa cells Concentration: 10 μM Incubation Time: 48 hours Result: Increased inα-tubulin acetylation, no change in the acetylation state of H3 was observed.

• 參考文獻：
  1. Olson DE, et, al. Discovery of the first histone deacetylase 6/8 dual inhibitors. J Med Chem. 2013 Jun 13;56(11):4816-20.

• 溶解性： soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.517 ml	17.586 ml	35.173 ml
  5 mM	0.703 ml	3.517 ml	7.035 ml
  10 mM	0.352 ml	1.759 ml	3.517 ml
  50 mM	0.07 ml	0.352 ml	0.703 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *