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• 產(chǎn)品描述： Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC50 and pKi of 8.73 and 9.3, respectively.

• 靶點(diǎn)： 5-HT2A Receptor:8.73 (pIC50);5-HT2A Receptor:9.3 (pKi)

• 體內(nèi)研究：
  Pimavanserin hemitartrate attenuates head-twitch behavior (3 mg/kg p.o.), and prepulse inhibition deficits (1-10 mg/kg s.c.) induced by the 5-HT2A receptor agonist in rats and reduces the hyperactivity induced in mice by the N-methyl-D-aspartate receptor noncompetitive antagonist, consistent with a 5-HT 2A receptor mechanism of action in vivo and antipsychotic-like efficacy. Pimavanserin hemitartrate demonstrates 42.6% oral bioavailability in rats

• 參考文獻(xiàn)：
  1. Vanover KE, et al. Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP- 103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May;317(2):910-8.

• 溶解性： DMSO  :  ≥  75  mg/mL  (149.23  mM)    H2O  :  50  mg/mL  (99.48  mM;  Need  ultrasonic)

• 保存條件： RT

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	0.995 ml	4.974 ml	9.948 ml
  5 mM	0.199 ml	0.995 ml	1.99 ml
  10 mM	0.099 ml	0.497 ml	0.995 ml
  50 mM	0.02 ml	0.099 ml	0.199 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *