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• 產(chǎn)品描述： ITD-1是有效的TGF-β抑制劑。它不抑制TGFBR1或TGFBR的激酶活性，但能夠有效地抑制TGFβ2誘導(dǎo)的效應(yīng)因子SMAD2/3磷酸化，對(duì)Activin A的影響甚微

• 靶點(diǎn)： TGF-β;TGF-beta/Smad

• 體外研究：
  ITD-1, a small molecule inhibitor of TGF-β signaling, can partially induce proteasomal degradation of the TβR232,33, and blocks Smad and MAPK activation

• 體內(nèi)研究：
  ITD-1 partially inhibits TGF-β signaling and renal fibrosis in unilateral ischemia-reperfusion injury (UIRI) mice

• 細(xì)胞實(shí)驗(yàn)： Cell lines: NRK-49F cells Concentrations: 3 μM Incubation Time: 1 h Method: NRK-49F cells are pre-incubated with KP1 (10?μg/ml, 3?μM) or ITD-1 (3?μM) for 1?h, and then treated with TGF-β1 (2?ng/ml) for 45?min. Western blot analyses the protein levels of p-Smad3 and p-p38.

• 參考文獻(xiàn)：
  1. Erik Willems, et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012, 11(2):242-52. 2. Yuan Q, et al. A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling. Nat Commun. 2022 Jan 21;13(1):438.

• 溶解性： soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.407 ml	12.033 ml	24.066 ml
  5 mM	0.481 ml	2.407 ml	4.813 ml
  10 mM	0.241 ml	1.203 ml	2.407 ml
  50 mM	0.048 ml	0.241 ml	0.481 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *