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• 產(chǎn)品描述： Sutezolid (PNU-100480), an orally active oxazolidinone antimicrobial agent, acts by inhibiting bacterial protein synthesis. Sutezolid has potent activity against mycobacteria, and is used for the research of drug-resistant tuberculosis

• 靶點： Oxazolidinone;Antibacterial;?Antibiotic

• 體外研究：
  Sutezolid (PNU-100480) exhibits excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s=0.5-4 μg/mL)

• 體內(nèi)研究：
  Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models

• 參考文獻(xiàn)：
  1. Barbachyn MR, et al. Identification of a novel oxazolidinone (U-100480) with potent antimycobacterial activity. J Med Chem. 1996;39(3):680-685. 2. Nicole Salazar-Austin, et al. Sutezolid. In Kucers the Use of Antibiotics: A Clinical Review of Antibacterial, Antifungal, Antiparasitic, and Antiviral Drugs, Seventh Edition (pp. 2559-2563). CRC Press. 3. Zhu T, et al. Population pharmacokinetic/pharmacodynamic analysis of the bactericidal activities of sutezolid (PNU-100480) and its major metabolite against intracellular Mycobacterium tuberculosis in ex vivo whole-blood cultures of patients with pulmonary tuberculosis. Antimicrob Agents Chemother. 2014;58(6):3306-3311.

• 溶解性： soluble  in  DMSO

• 保存條件： -20℃

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.83 ml	14.148 ml	28.296 ml
  5 mM	0.566 ml	2.83 ml	5.659 ml
  10 mM	0.283 ml	1.415 ml	2.83 ml
  50 mM	0.057 ml	0.283 ml	0.566 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計算器可幫助您計算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *