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• 產(chǎn)品描述： C75 trans (trans-C75, (±)-C75) 是一種 fatty acid synthase (FAS/FASN) 的新型有效的合成抑制劑，在成株試驗(yàn)和球體生長(zhǎng)測(cè)定中的IC50值分別為35 μM和50 μM。C75 可用作研究代謝紊亂和癌癥中脂肪酸合成的工具

• 靶點(diǎn)： FASN(clonogenic assay):35 μM;FASN(spheroid growth assay):50 μM;FattyAcidSynthase

• 體內(nèi)研究：
  C75 inhibits fatty acid synthesis and in vivo mammary cancer development. C75 treatment prevents mammary cancer development and retards mammary development in neu-N transgenic mice.

• 細(xì)胞實(shí)驗(yàn)： Cell lines: PC3 cells, LNCaP cells Concentrations: 5 μM, 25 μM, 35 μM, 50 μM Incubation Time: 3 h, 6 h, 24 h Method: PC3 cells are seeded in 25 cm2 flasks at 105 cells/flask. When cultures are in exponential growth phase, media is removed and replaced with fresh drug-containing media. Cells are then incubated for 24 h at 37℃ in 5% CO2. To determine optimal sequencing of therapeutic agents, three different combination treatment schedules are assessed: 1. radiation and C75 administered simultaneously; 2. radiation administered 24 h before C75; and 3. radiation administered 24 h after C75. After treatment, cells are seeded for clonogenic survival assay.

• 動(dòng)物實(shí)驗(yàn)： Animal Models: neu-N transgenic mice, FVB/N mice Dosages: 30mg/kg Administration: IP

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存條件： -20℃;干燥

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	3.932 ml	19.66 ml	39.321 ml
  5 mM	0.786 ml	3.932 ml	7.864 ml
  10 mM	0.393 ml	1.966 ml	3.932 ml
  50 mM	0.079 ml	0.393 ml	0.786 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號(hào)：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *