S84805 |
KY1220 |
MedMol | 98% |
品牌 | 貨號 | 產(chǎn)品規(guī)格 | 價格(RMB) | 庫存(上海) | 北京 | 武漢 | 南京 | 數(shù)量 | 計量單位 | 加入購物車... |
---|---|---|---|---|---|---|---|---|---|---|
MedMol | S84805-2mg | 98% | ¥374.00元 | 5 | - | - | - | EA | 加入購物車 | |
MedMol | S84805-5mg | 98% | ¥697.00元 | 6 | - | - | - | EA | 加入購物車 | |
MedMol | S84805-10mg | 98% | ¥940.00元 | 6 | - | - | - | EA | 加入購物車 | |
MedMol | S84805-25mg | 98% | ¥1600.00元 | 5 | - | - | - | EA | 加入購物車 | |
MedMol | S84805-50mg | 98% | ¥2390.00元 | 5 | - | - | - | EA | 加入購物車 | |
源葉(MedMol) | S84805-100mg | 98% | ¥3390.00元 | 預(yù)計交期:2-3天 | - | - | - | EA | 加入購物車 |
- 提示:詳情請下載說明書。
- 產(chǎn)品描述: KY1220 is a compound that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway; with an IC50 of 2.1 μM in HEK293 reporter cells.
- 靶點: IC50: 2.1 μM (HEK293 reporter cells);Wnt/beta-catenin
- 體外研究:
KY1220 shows an IC50 of 2.1 μM in HEK293 reporter cells. KY1220 dose dependently decreases Wnt3a-CM-induced TOPflash reporter activation and mRNA expression of Wnt target genes CCND1 and MYC in HEK293 cells. In HEK293 cells, both β-catenin and panRas protein levels are similarly reduced in a dose-dependent manner after treatment with KY1220, whereas the mRNA levels of CTNNB1 (which encodes β-catenin), NRAS, KRAS and HRAS remain unchanged. K-Ras, which has a critical role in progression of CRCs, is also destabilized by KY1220 via polyubiquitin-dependent proteasomal degradation. KY1220 accelerates the degradation rates of both β-catenin and Ras in SW480 cell lines. Ras destabilization by KY1220 consequently inhibits the activities of both ERK and Akt, which are downstream effectors of Ras in SW480 cells harboring a KRAS mutation. The proliferation and transformation of the HCT15, SW480, D-WT and D-MT CRC cells are efficiently inhibited after treatment with KY1220
- 參考文獻(xiàn):
1. Cha PH, et al. Small-molecule binding of the axin RGS domain promotes β-catenin and Ras degradation. Nat Chem Biol. 2016 Aug;12(8):593-600.
- 溶解性: Soluble in DMSO
- 保存條件: -20℃
- 配置溶液濃度參考:
1mg 5mg 10mg 1 mM 3.181 ml 15.907 ml 31.815 ml 5 mM 0.636 ml 3.181 ml 6.363 ml 10 mM 0.318 ml 1.591 ml 3.181 ml 50 mM 0.064 ml 0.318 ml 0.636 ml
- 注意:部分產(chǎn)品我司僅能提供部分信息,我司不保證所提供信息的權(quán)威性,僅供客戶參考交流研究之用。
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