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• 產(chǎn)品描述： TC-H 106 (Pimelic Diphenylamide 106)是一種慢速、緊密結(jié)合的I類histone deacetylases(HDAC)抑制劑，對HDAC1, HDAC2, HDAC3的Ki值分別為148 nM, 約102 nM, 14 nM

• 靶點(diǎn)： HDAC3(Cell-free assay):14 nM(Ki);HDAC2(Cell-free assay):~102 nM(Ki)HDAC1(Cell-free assay):148 nM(Ki);HDAC

• 細(xì)胞實(shí)驗(yàn)： Cell lines: lymphoblastoid cell line Concentrations: 2 μM Incubation Time: 24 h Method: Cells are cultured in RPMI 1640 media with 10% fetal bovine serum and 10 mM HEPES, at 37 °C in 5% CO2. After the 5th split, the cells are treated with inhibitor TC-H 106 (2 μM) for 24 h, in culture medium. 24 h after treatment, the cells are washed twice with Hanks' balanced salts buffer to remove the inhibitor. A portion of the cell population is then harvested immediately after washing, and referred to as a time 0 point (24 h treatment point), and the rest of the cells are then re-cultured in cell culture media without added inhibitor. The re-cultured cells and controls are then harvested every hour for a total of 7 h.

• 參考文獻(xiàn)：
  1. Chou CJ, et al. J Biol Chem. 2008 19;283(51):35402-9.

• 溶解性： Soluble  in  DMSO、Ethanol

• 保存條件： 2-8℃，避光

• 配置溶液濃度參考：
  

  	1mg	5mg	10mg
  1 mM	2.946 ml	14.731 ml	29.461 ml
  5 mM	0.589 ml	2.946 ml	5.892 ml
  10 mM	0.295 ml	1.473 ml	2.946 ml
  50 mM	0.059 ml	0.295 ml	0.589 ml

• 注意：部分產(chǎn)品我司僅能提供部分信息，我司不保證所提供信息的權(quán)威性，僅供客戶參考交流研究之用。

輸入產(chǎn)品批號：

本計(jì)算器可幫助您計(jì)算出特定溶液中溶質(zhì)的質(zhì)量、溶液濃度和體積之間的關(guān)系，公式為：

質(zhì)量 (mg) = 濃度 (mM) x 體積 (mL) x 分子摩爾量 (g/mol)

• pg ng μg mg g kg =
  fM pM nM μM mM M *
  nL μL mL L *